- Great Lakes Airlines was a regional airline based in Cheyenne, Wyoming, in the United States. The airline operated flights primarily in the midwestern and western regions of the country. It was founded in 1977 and began its operations with a focus on providing service to smaller communities in the Great Lakes region. However, the airline faced financial difficulties and suspended operations in March 2018. In a statement, the company cited a shortage of pilots as the main reason for the suspension. As of now, there is no information about whether Great Lakes Airlines will resume operations in the future.